رسوراترول می تواند از عضلات بدن در گرانش جزئی مریخ محافظت کند

The effects of partial جاذبه زمین (example on مارس) on our muscular system is still partly understood. Study in rats shows that resveratrol, a compound found in grape skin and red wine, can mitigate muscle impairment in a مارس جزئي جاذبه زمین model. This can be beneficial to sustain long-term مارس ماموریت ها

اداره ملی هوانوردی و فضا (ناسا) of USA is planning to send astronauts to Moon and مارس. میکروگرانش بر سیستم عضلانی بدن ما تأثیر می گذارد عضلات and bones start to become weak. First, weight-bearing muscles like soleus, located in the calf are affected and then slow-twitch muscle fibers are lost. Mars’s gravitational pull is only 40 percent of Earth’s thus it has a lower gravity of 0.38g. It is still not completely understood how such گرانش جزئی can affect our body. No partial weight-bearing model has been tested until now which can mimic Martian partial gravity. More understanding in this area is critical in order to plan long space missions to مارس and safe return of astronauts to Earth.

یک مطالعه جدید در 18 جولای در مرزهای فیزیولوژی has used recently developed partial weight-bearing animal models of simulated مارس partial gravity to understand how muscle deconditioning could be addressed on long مارس space missions. To simulate gravity of مارس, rats were fitted with full-body harness and were suspended from their cage ceiling. Divided into two groups, rats were exposed to normal loading (of Earth’s) or 40 percent loading of مارس for 2 weeks. Half the number of rats in each group received either رسوراترول (RSV) - پلی فنول ایمن که معمولا در پوست انگور، شراب قرمز و زغال اخته - در آب یا فقط آب یافت می شود. حیوانات آزادانه از رژیم غذایی چو تغذیه می کردند.

In مارس condition, rats’ grip weakened and their calf circumference, muscle weight and slow-twitch fiber content got shrunk. Calf circumference and front and rear paw grip force were measured weekly while calf muscles were analyzed after 2 weeks . Results showed that a moderate daily dose (150 mg/kg/day) of resveratrol was seen to preserve muscle mass and strength in animals exposed to the effects of a simulated مارس gravity. RSV helped restore front and rear paw grips and protected muscle mass in مارس rat while having no effect on diet or body weight. RSV is known to have anti-inflammatory, anti-oxidative and anti-diabetic effects. It has been shown to promote muscle growth in diabetic animals by increasing insulin sensitivity and glucose uptake in muscle fibers. Astronauts are thought of developing reduced insulin sensitivity during space missions.

Resveratrol is seen to have a muscle-protective effect as it preserves bone and muscle mass. The current study suggests that resveratrol can help to mitigate muscle impairment in a مارس partial gravity analog which mimics مارس environment. It could be used as a nutritional supplement to reduce muscle and skeletal deconditioning and deterioration on long-term مارس ماموریت ها

***

{شما می‌توانید مقاله پژوهشی اصلی را با کلیک بر روی پیوند DOI که در فهرست منابع ذکر شده در زیر آمده است بخوانید}

منبع (ها)

Mortreux, M. 2019. یک دوز متوسط ​​روزانه از رسوراترول باعث کاهش شرایط عضلانی در آنالوگ گرانش مریخ می شود. جلو. فیزیول.
https://doi.org/10.3389/fphys.2019.00899